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Synbiotics provide a SIGNIFICANT ADDITIONAL BENEFIT for improving the
Synbiotics not only have a supportive effect on the immune system, but also have a preventive effect with the potential to minimize susceptibility to disease. Synbiotics have added health value, even if you are already ill. During severe infections, synbiotics can contribute to a significantly milder course due to their supportive effect. Very valid and recent studies that have been carried out internationally by renowned universities have provided a reliable database attesting to the positive effect of synbiotics and future application possibilities.
Note: The scientific publications listed here were not initiated by AASAYA LifeScience GmbH.
THE IMMUNE SYSTEM
Synbiotics serve to promote the growth and activity of beneficial bacteria in the intestine and strengthen the immune system.
Amitay, Efrat L. MPH, PhD1; Carr, Prudence R. PhD1; Gies, Anton PhD2; Laetsch, Dana Clarissa PhD1; Brenner, Hermann MD, MPH1,2,3 Probiotic/Synbiotic Treatment and Postoperative Complications in Colorectal Cancer Patients: Systematic Review and Meta-analysis of Randomized Controlled Trials, Clinical and Translational Gastroenterology: December 2020 - Volume 11 - Issue 12 – p e00268 https://doi.org/10.14309/ctg.0000000000000268
Added value of synbiotics
The results of a systematic review showed that the administration of probiotics/synbiotics to colorectal cancer patients before, during, and after surgery was associated with a lower incidence of infections, lower incidence of diarrhoeal diseases, faster return to normal intestinal function, shorter periods of postoperative antibiotic use, lower incidence of septicaemia or generalized infections of the organism, and shorter lengths of hospital stays. The results support the hypothesis that short-term perioperative administration of probiotics/synbiotics, which are easy to administer, have few side effects and are inexpensive compared to alternatives, and they could help reduce gastrointestinal symptoms and postoperative complications in colorectal cancer patients.
PREVENTION AND EFFECT ON
The fibre-induced microbial changes [...] have a significant influence on the immune system and thus on the prevention and treatment of diseases.
Cai Y, Folkerts J, Folkerts G, Maurer M, Braber S. Microbiota-dependent and -independent effects of dietary fibre on human health. Br J Pharmacol. 2020 Mar;177(6):1363-1381. https://doi.org/10.1111/bph.14871. Epub 2019 Dec 12. PMID: 31663129; PMCID: PMC7056464.
Importance of dietary fibre for health
In the gastrointestinal tract, dietary fibre promotes beneficial bacteria, such as bifidobacteria and lactobacilli. Bifidobacteria and lactobacilli have been shown to compete directly with pathogenic (disease-causing) bacteria, but can also stimulate the intestinal barrier and immune and brain function. These dietary fibres not only stimulate beneficial bacteria, but they also directly influence pathogens by a) inhibiting growth, b) reversing the damaging effect on healthy cells, c) inhibiting pathogen-induced toxin production. A significant part of these potential health benefits is related to the production of microbial metabolites from dietary fibre, including SCFAs (short-chain fatty acids).
IRRITABLE BOWEL SYNDROME
Significant reduction of IBS symptoms with probiotics.
Ford, Alexander C MB ChB, MD, FRCP; Moayyedi, Paul BSc, MB ChB, PhD, MPH, FACG; Lacy, Brian E MD, PhD, FACG; Lembo, Anthony J MD; Saito, Yuri A MD, MPH5; Schiller, Lawrence R MD, FACG; Soffer, Edy E MD, FACG; Spiegel, Brennan M R MD, FACG; Quigley, Eamonn M M MD, FACG for the Task Force on the Management of Functional Bowel Disorders. American College of Gastroenterology Monograph on the Management of Irritable Bowel Syndrome and Chronic Idiopathic Constipation. American Journal of Gastroenterology: August 2014 - Volume 109 - Issue - p S2-S26 https://doi.org/10.1038/ajg.2014.187
“Irritable bowel syndrome (IBS): Certain probiotics have been shown to relieve the symptoms of IBS and improve the quality of life of IBS patients.”
A guideline and meta-analysis involving children and adults with IBS found that probiotics significantly improved IBS symptoms, such as bloating and flatulence.
The duration of treatment with antibiotics can be reduced. The intestinal microbiota attacked by antibiotics can regenerate more quickly.
Nature Microbiology, “Probiotics impact the antibiotic resistance gene reservoir along the human GI tract in a person-specific and antibiotic-dependent manner”, August 2021, in Cooperation with German Cancer Research Center, Heidelberg and Johns Hopkins Bloomberg School of Public Health, Baltimore https://doi.org/10.1038/s41564-021-00920-0
PROBIOTICS AND THEIR INFLUENCE ON UPPER RESPIRATORY TRACT INFECTIONS
Influencing the gut microbiota is a promising approach to combat viral respiratory disease by regulating the innate and acquired immune system. Probiotics have shown to have a beneficial impact on reducing the severity and duration of upper respiratory tract infections. Particularly respiratory-syncytial viruses (RS viruses), COVID-19 and influenza (flu).
Shi, H.Y., Zhu, X., Li, W.L. et al. Modulation of gut microbiota protects against viral respiratory tract infections: a systematic review of animal and clinical studies. Eur J Nutr 60, 4151–4174 (2021). https://doi.org/10.1007/s00394-021-02519-x
Nature Portfolio Journal, “Gut microbiome dysbiosis during COVID-19 is associated with increased risk for … microbial translocation”, July 2021, Yale University and New York University Grossman School of Medicine https://doi.org/10.21203/rs.3.rs-726620/v1
The current COVID-19 pandemic has changed the face of biology, social interaction, and public health worldwide. It had a devastating impact on millions of people all over the globe. New evidence suggests a link between infection and the status of the intestinal microbiome. This is one of several factors that can contribute to the severity of the infection. Given that the intestine is strongly linked to immunity, inflammatory status, and the ability to fight pathogens, it is worth considering a dietary intervention in the intestinal microbiota as a means of potentially influencing viral outcomes. In this context, probiotics and prebiotics have been used to mitigate similar respiratory infections.
IMPROVEMENT OF MENTAL WELL-BEING
A microbiome-based holistic approach, which involves carefully annotating the microbiome and potential modification through diet, probiotics, and lifestyle changes, may address depression.
Frontiers in Nutrition, “A Microbiome-Driven Approach to Combating Depression During the COVID-19 Pandemic”, August 2021, in Cooperation with University Hospitals Cleveland Medical Center https://doi.org/10.3389/fnut.2021.672390
Psyche and resilience
Feel good, even in the pandemic: during these times of COVID-19, many people complain about feeling depressed and being in a poor mood. Specially formulated probiotics promote mental well-being by supporting the normal functions of the brain and psyche, thereby increasing resilience. The mode of action is based on a targeted response to the gut-brain axis (GBA).
ALLERGIES AND SKIN CONDITIONS
Microbiome as a therapeutic target for inflammatory diseases, such as allergies and skin disease.
Pascal M, Perez-Gordo M, Caballero T, Escribese MM, Lopez Longo MN, Luengo O, Manso L, Matheu V, Seoane E, Zamorano M, Labrador M and Mayorga C (2018) Microbiome and Allergic Diseases. Front. Immunol. 9:1584. https://doi.org/10.3389/fimmu.2018.01584
The prevalence of allergic diseases, such as respiratory, skin disease, and food allergies, has dramatically increased in recent decades. Recent research confirms that the microbiome, which is strongly influenced by several environmental and nutritional factors, plays a central role.
Bacterial dysbiosis is associated with chronic inflammatory diseases of the skin, such as atopic dermatitis and psoriasis. Thus, the microbiome is an important therapeutic target for the treatment of inflammatory diseases, such as allergies.
Despite some limitations, interventions with probiotics, prebiotics, and/or synbiotics seem promising for the development of preventive therapy by restoring altered microbiome function or as a supplement to specific immunotherapy.
Probiotics reduce the risk of antibiotic-associated diarrhoea.
Goldenberg JZ, Yap C, Lytvyn L, Lo CK, Beardsley J, Mertz D, Johnston BC. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst Rev. 2017 Dec 19; 12(12):CD006095. https://doi.org/10.1002/14651858.CD006095.pub4. PMID: 29257353; PMCID: PMC6486212.
“Clinical trials with various probiotic compounds suggest a beneficial effect of certain probiotics on the initial onset as well as the severity of existing Clostridium difficile-associated diarrhoea and AAD.”
Antibiotic-associated diarrhoea (AAD): Although antibiotics are essential for treating bacterial infections, they can also disrupt the beneficial bacterial community in the gastrointestinal tract. Due to disruption of the intestinal microbiota, the occurrence of secondary infections caused by opportunistic pathogens, such as Clostridium difficile, is a complication of concern in hospitalised older adults.